SCHEMBL28319035

SCHEMBL28319035

CC(C)n1cnc2c(N)nc(Cc3ccc(F)cc3)nc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 9/20 0.55
CDK2 P24941 6/20 0.55
CCNB1 P14635 5/20 0.55
CCNE1 P24864 4/20 0.55
ADORA2A P29274 1/20 0.46
ADORA2B P29275 1/20 0.46
ADORA1 P30542 1/20 0.46
PI4KA P42356 1/20 0.46
PI4K2B Q8TCG2 1/20 0.46
PI4K2A Q9BTU6 1/20 0.46
PI4KB Q9UBF8 1/20 0.46
CCNA2 P20248 2/20 0.43
CCNA1 P78396 2/20 0.43
CCNE2 O96020 1/20 0.43
HTR6 P50406 1/20 0.39
KDM4E B2RXH2 2/20 0.39
NPC1 O15118 2/20 0.39
MAPT P10636 2/20 0.39
CDK5 Q00535 2/20 0.39
DYRK1A Q13627 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28320166 0.86 CDK1 (0.50) CDK1CDK2CCNB1CCNE1ADORA2A
SCHEMBL14039518 0.75 CDK1 (0.71) CDK1CDK2CCNB1CCNE1ADORA2A
SCHEMBL7707871 0.75 CDK1 (0.61) CDK1CDK2CCNB1CCNE1ADORA2A
SCHEMBL24474439 0.73 CDK1 (0.58) CDK1CDK2CCNB1CCNE1ADORA2A
SCHEMBL27560688 0.72 CDK2 (0.61) CDK1CDK2CCNB1CCNE1CCNA2
SCHEMBL756644 0.72 CDK1 (1.00) CDK1CDK2CCNB1CCNE1ADORA2A
SCHEMBL29611365 0.72 CDK1 (1.00) CDK1CDK2CCNB1CCNE1ADORA2A
SCHEMBL31576041 0.72 USP1 (0.42) CDK1CDK2CCNB1CCNE1
SCHEMBL19111968 0.71 CDK2 (0.48) CDK1CDK2CCNB1CCNE1CCNA2
SCHEMBL784159 0.70 CDK2 (0.73) CDK1CDK2CCNB1CCNE1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110256436-A Purine compound as Trk kinase inhibitor 南京雷正医药科技有限公司 2019-09-20 CN disclosed