Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | PLCG1 | P19174 | 5/20 | 0.46 |
| ▸ | ITK | Q08881 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16334895 | 0.82 | BTK (0.71) | BTKJAK3MAP2K7AURKA | |
| SCHEMBL18499568 | 0.82 | BTK (0.54) | BTKJAK3MAP2K7AURKAPLCG1 | |
| SCHEMBL28320056 | 0.82 | BTK (0.51) | BTKJAK3MAP2K7AURKAPLCG1 | |
| SCHEMBL28320196 | 0.78 | KIT (0.39) | JAK3AURKAITK | |
| SCHEMBL28321217 | 0.73 | BTK (0.51) | BTKJAK3PLCG1JAK1 | |
| SCHEMBL24150242 | 0.70 | BTK (0.64) | BTKJAK3MAP2K7AURKAPLCG1 | |
| SCHEMBL30191052 | 0.70 | BTK (0.64) | BTKJAK3MAP2K7AURKAPLCG1 | |
| SCHEMBL12965715 | 0.70 | BTK (1.00) | BTKJAK3MAP2K7AURKAPLCG1 | |
| SCHEMBL28320003 | 0.68 | BTK (0.73) | BTKJAK3PLCG1JAK1 | |
| SCHEMBL16336935 | 0.67 | BTK (1.00) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105530932-B | Primary formamide as BTK inhibitor | 艾伯维公司 | 2019-09-27 | — | — | CN | disclosed |