Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL27686921 | 1.00 | TDP1 (0.53) | TDP1OR51E2TP53TSHRAKR1B1 | |
| Propylene Glycol SCHEMBL20496490 | 0.92 | TDP1 (0.50) | TDP1OR51E2TP53TSHRAKR1B1 | |
| Propylene Glycol SCHEMBL2026277 | 0.89 | TDP1 (0.67) | TDP1TSHRAKR1B1LMNAALDH1A1 | |
| Propylene Glycol SCHEMBL159902 | 0.89 | — | — | |
| Propylene Glycol SCHEMBL8145561 | 0.89 | TDP1 (0.67) | TDP1TSHRAKR1B1LMNAALDH1A1 | |
| Propylene Glycol SCHEMBL4596786 | 0.89 | TDP1 (0.67) | TDP1TSHRAKR1B1LMNAALDH1A1 | |
| Methacrylic Acid SCHEMBL17974554 | 0.86 | TDP1 (0.43) | TDP1OR51E2TP53TSHRALDH1A1 | |
| Propylene Glycol SCHEMBL11859164 | 0.86 | TDP1 (0.62) | TDP1TSHRAKR1B1LMNAALDH1A1 | |
| Propylene Glycol SCHEMBL28505248 | 0.86 | TDP1 (0.62) | TDP1OR51E2TP53TSHRPDE4A | |
| Propylene Glycol SCHEMBL28574118 | 0.86 | TDP1 (0.71) | TDP1OR51E2TP53TSHRPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110147031-A | The manufacturing method and display device of photosensitive polymer combination, heat-resistant resin film | 东丽株式会社 | 2019-08-20 | — | — | CN | disclosed |
| CN-104854508-B | The manufacturing method and display device of photosensitive polymer combination, heat-resistant resin film | 东丽株式会社 | 2019-05-07 | — | — | CN | disclosed |