Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | ILK | Q13418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2832760 | 0.85 | TSHR (0.43) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL2826267 | 0.82 | SMN1; SMN2 (0.45) | MEN1KMT2AATMALDH1A1TSHR | |
| SCHEMBL2825669 | 0.80 | TSHR (0.44) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL2827898 | 0.80 | HCAR3 (0.45) | MEN1KMT2AALDH1A1TSHRCYP2C19 | |
| SCHEMBL9295807 | 0.80 | PDE5A (0.43) | MEN1KMT2APDE4BALDH1A1TSHR | |
| SCHEMBL1359449 | 0.79 | TSHR (0.43) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL18467314 | 0.79 | TSHR (0.43) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL2825763 | 0.78 | PTGER4 (0.48) | ALDH1A1TSHRLMNASMN1; SMN2MAPT | |
| SCHEMBL16371512 | 0.78 | TSHR (0.46) | KMT2AALDH1A1TSHRCYP1A2CYP2C19 | |
| SCHEMBL2827013 | 0.77 | MEN1 (0.60) | MEN1KMT2AALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988378-B2 | 1 H-pyrazole and 4,5-disubstituted thiazole inhibitors of SYK | HOFFMANN-LA ROCHE INC. (CH) | 2018-06-05 | — | — | US | disclosed |
| US-9988378-B2 | 1 H-pyrazole and 4,5-disubstituted thiazole inhibitors of SYK | HOFFMANN-LA ROCHE INC. (CH) | 2018-06-05 | — | — | US | disclosed |
| US-9988378-B2 | 1 H-pyrazole and 4,5-disubstituted thiazole inhibitors of SYK | HOFFMANN-LA ROCHE INC. (CH) | 2018-06-05 | — | — | US | disclosed |
| US-20150266874-A1 | 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-09-24 | — | — | US | disclosed |
| US-20150266874-A1 | 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-09-24 | — | — | US | disclosed |
| US-20150266874-A1 | 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-09-24 | — | — | US | disclosed |
| CN-104640850-A | 3,4-disubstituted 1 H-pyrazole and 4,5-disubstituted thiazole inhibitors of SYK | HOFFMANN LA ROCHE | 2015-05-20 | — | — | CN | disclosed |
| WO-2014064134-A1 | 3,4-DISUBSTITUTED 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-01 | — | — | WO | disclosed |
| WO-2014064134-A1 | 3,4-DISUBSTITUTED 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-01 | — | — | WO | disclosed |
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | disclosed |
| US-7678815-B2 | Thiazole-4-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| US-20060160857-A1 | Thiazole-4-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. | 2006-07-20 | — | — | US | disclosed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160857-A1 | Thiazole-4-carboxyamide derivatives | GRM1, GRM2, GRIA4 | MEN1 2558/4885KMT2A 1012/4885ATM 4531/4885 |
| US-20150266874-A1 | 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | SYK, BTK, IRAK4 | MEN1 3071/4885KMT2A 896/4885ATM 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.