Quinolin-4-Amine

Quinolin-4-Amine

SCHEMBL28326164

CCOCc1nc2cnc3ccccc3c2n1CC(C)(C)N.Nc1ccnc2ccccc12

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 16/20 0.52
TLR8 Q9NR97 13/20 0.52
NUDT1 P36639 1/20 0.51
NCF1 P14598 1/20 0.40
PDE10A Q9Y233 1/20 0.34
MEN1 O00255 1/20 0.34
TSHR P16473 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4130348 0.92 TLR7 (0.57) TLR7TLR8NUDT1MEN1TSHR
SCHEMBL1706194 0.81 TLR7 (0.67) TLR7TLR8NUDT1
SCHEMBL4313723 0.80 TLR7 (0.55) TLR7TLR8NUDT1MEN1TSHR
SCHEMBL4317842 0.80 TLR7 (0.53) TLR7TLR8NUDT1MEN1TSHR
SCHEMBL5617122 0.79 TLR7 (0.53) TLR7TLR8NUDT1
SCHEMBL18179115 0.79 TLR7 (0.49) TLR7TLR8NUDT1PDE10AMEN1
SCHEMBL31581121 0.78 TLR7 (0.71) TLR7TLR8NUDT1MEN1TSHR
SCHEMBL29978112 0.78 TLR7 (0.71) TLR7TLR8NUDT1MEN1TSHR
SCHEMBL5617120 0.78 TLR7 (0.54) TLR7TLR8NUDT1MEN1TSHR
SCHEMBL1486719 0.77 TLR8 (0.44) TLR7TLR8NUDT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110290810-A Antibody adjuvant conjugate 博尔特生物治疗药物有限公司 2019-09-27 CN disclosed