Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.35 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28117488 | 0.79 | HRH4 (0.39) | HRH3 | |
| SCHEMBL24379246 | 0.77 | KCNJ1 (0.40) | PDE10ADEGS1MAPK8MAPK10RXRA | |
| SCHEMBL27253445 | 0.73 | HRH3 (0.52) | PDE10AMAPK8MAPK10HRH3 | |
| SCHEMBL20046932 | 0.71 | HRH3 (0.42) | PDE10ARXRAHRH3 | |
| SCHEMBL24411118 | 0.71 | PDE10A (0.46) | PDE10ADEGS1MAPK8MAPK10RXRA | |
| SCHEMBL28951039 | 0.70 | MAPK14 (0.30) | — | |
| SCHEMBL24379245 | 0.70 | SMO (0.53) | HRH3 | |
| SCHEMBL30432036 | 0.70 | SMO (0.53) | HRH3 | |
| SCHEMBL28330703 | 0.67 | KDM4E (0.55) | — | |
| SCHEMBL19598739 | 0.67 | HRH3 (0.54) | PDE10AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110506039-A | Compounds and methods for targeted degradation of androgen receptor | ARVINAS INC | 2019-11-26 | — | — | CN | disclosed |