Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28330751 | 0.79 | PDE10A (0.35) | HRH3 | |
| SCHEMBL9925949 | 0.78 | HRH4 (0.51) | HRH4HTR3AHRH3 | |
| SCHEMBL27767055 | 0.74 | AOC3 (0.43) | HRH4HTR3AAOC3HRH3RAB9A | |
| SCHEMBL28630846 | 0.72 | TDP1 (0.49) | HRH4HTR3ATDP1HRH3RAB9A | |
| SCHEMBL81828 | 0.69 | HTR3A (0.52) | HRH4HTR3AHRH3RAB9AL3MBTL1 | |
| SCHEMBL2322917 | 0.68 | ALDH1A1 (0.57) | HRH4HTR3ATDP1RAB9AL3MBTL1 | |
| SCHEMBL28092474 | 0.68 | — | — | |
| SCHEMBL28951039 | 0.68 | MAPK14 (0.30) | — | |
| SCHEMBL28092253 | 0.67 | SIRT6 (0.43) | — | |
| SCHEMBL28133716 | 0.67 | KCNH2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146493-A | Pyrazolo [3,4-b] pyridines and the preparation method of indazole compounds and purposes | 中国科学院上海药物研究所 | 2016-11-23 | — | — | CN | disclosed |