Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 5/20 | 0.54 |
| ▸ | CA9 | Q16790 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30076512 | 0.91 | CA12 (0.52) | KMT2AMEN1KDM4EUSP2POLB | |
| SCHEMBL3454762 | 0.87 | CA12 (0.55) | KMT2AMEN1KDM4EUSP2POLB | |
| SCHEMBL14397821 | 0.87 | KMT2A (0.47) | KMT2AMEN1KDM4EUSP2POLB | |
| SCHEMBL29941371 | 0.85 | KMT2A (0.47) | KMT2AMEN1KDM4EUSP2POLB | |
| SCHEMBL30076519 | 0.85 | CA12 (0.53) | KMT2AMEN1KDM4EUSP2POLB | |
| SCHEMBL11170567 | 0.84 | KMT2A (0.56) | KMT2AMEN1KDM4EUSP2POLB | |
| SCHEMBL9210466 | 0.81 | CA12 (0.53) | KMT2AMEN1KDM4EUSP2POLB | |
| SCHEMBL29385278 | 0.80 | MCL1 (0.59) | POLBCA12CA9SMN1; SMN2TSHR | |
| SCHEMBL5515234 | 0.80 | MCL1 (0.59) | POLBCA12CA9SMN1; SMN2TSHR | |
| SCHEMBL6112522 | 0.79 | RAB9A (0.54) | KMT2AMEN1POLBCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138955-A2 | METHODS AND COMPOSITIONS FOR TREATING NEOPLASIA | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-12-02 | — | — | WO | claimed |
| EP-0416499-A2 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-13 | — | — | EP | disclosed |