Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22470600 | 0.81 | MCHR1 (0.44) | SCN9A | |
| SCHEMBL22957638 | 0.79 | HTR2A (0.41) | SCN9ASCN5AHTR2AHTR2CHTR2B | |
| SCHEMBL28331581 | 0.78 | PARP10 (0.36) | SCN9ASCN5APARP10HTR2AHTR2C | |
| SCHEMBL24180164 | 0.76 | PARP10 (0.43) | SCN9ASCN5APARP10HTR2AHTR2C | |
| SCHEMBL28331543 | 0.76 | CYP19A1 (0.45) | SCN9ASCN5AHTR2AHTR2CHTR2B | |
| SCHEMBL24499219 | 0.76 | SCN9A (0.39) | SCN9ASCN5APARP10PDE4APDE4B | |
| SCHEMBL28331549 | 0.75 | HTR2C (0.45) | SCN9AHTR2AHTR2CHTR2BPDE4A | |
| SCHEMBL24018791 | 0.75 | SCN9A (0.39) | SCN9ASCN5APARP10HTR2AHTR2C | |
| SCHEMBL22957828 | 0.74 | SCN9A (0.39) | SCN9ASCN5AHTR2AHTR2CHTR2B | |
| SCHEMBL20472323 | 0.74 | HTR2A (0.41) | SCN9APARP10HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110520423-B | Aminotriazolopyridines as kinase inhibitors | 百时美施贵宝公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-110520423-A | AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO | 2019-11-29 | — | — | CN | disclosed |