Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | L3MBTL4 | Q8NA19 | 2/20 | 0.47 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GPR183 | P32249 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13090286 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL3L3MBTL1L3MBTL4MBTD1 | |
| SCHEMBL13636007 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL4381584 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL14190929 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL4381901 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL3767758 | 0.85 | GPR183 (0.41) | SMN1; SMN2HPGDTSHRKDM4EAR | |
| SCHEMBL3767754 | 0.85 | GPR183 (0.41) | SMN1; SMN2HPGDTSHRKDM4EAR | |
| SCHEMBL14218062 | 0.82 | GPR183 (0.61) | SMN1; SMN2HPGDTSHRKDM4EAR | |
| SCHEMBL13090259 | 0.81 | PELI1 (0.52) | SMN1; SMN2L3MBTL3L3MBTL1L3MBTL4MBTD1 | |
| SCHEMBL14190909 | 0.80 | GPR183 (0.55) | SMN1; SMN2HPGDTSHRKDM4EAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |