Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10166462 | 0.81 | MAPK1 (0.41) | CYP1A2GAACYP2C19 | |
| SCHEMBL15723543 | 0.81 | XDH (0.45) | PCSK9MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3752006 | 0.78 | MAPT (0.40) | BRD4PCSK9MAPTGAA | |
| SCHEMBL24185658 | 0.78 | NPC1 (0.40) | BRD4PCSK9MAPTGAA | |
| SCHEMBL21849283 | 0.78 | CYP1A2 (0.41) | MAPTCYP1A2CYP17A1CYP2C9CYP2C19 | |
| SCHEMBL18292376 | 0.78 | MAPK10 (0.39) | MAPK9MAPK10MAPK8FLT3CHKA | |
| SCHEMBL17457966 | 0.75 | MEN1 (0.37) | MAPK9MAPK10MAPK8CHKAAR | |
| Bromide SCHEMBL11376966 | 0.73 | XDH (0.47) | MAPTCYP1A2CYP2C9 | |
| SCHEMBL12490105 | 0.72 | MEN1 (0.50) | MAPTGAA | |
| SCHEMBL15783976 | 0.71 | ATR (0.43) | MAPTCYP1A2CYP3A4GAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107501274-B | It can be used as the compound of ATR kinase inhibitor | Votex Pharmaceutical Co., Ltd. (US) | 2019-11-22 | — | — | CN | disclosed |
| CN-107501275-B | It can be used as the compound of ATR kinase inhibitor | Votex Pharmaceutical Co., Ltd. (US) | 2019-11-22 | — | — | CN | disclosed |