Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 13/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PTGFR | P43088 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22497617 | 1.00 | MAPK1 (0.49) | MAPK1MAPK3MEN1NPC1RAB9A | |
| SCHEMBL28335674 | 0.88 | MAPK1 (0.53) | MAPK1MAPK3 | |
| SCHEMBL28335678 | 0.88 | MAPK1 (0.53) | MAPK1MAPK3 | |
| SCHEMBL20916811 | 0.86 | MAPK1 (0.53) | MAPK1MAPK3CYP3A4 | |
| SCHEMBL20916856 | 0.86 | MAPK1 (0.53) | MAPK1MAPK3CYP3A4 | |
| SCHEMBL20931371 | 0.86 | MAPK1 (0.53) | MAPK1MAPK3CYP3A4 | |
| SCHEMBL30554347 | 0.86 | MAPK1 (0.53) | MAPK1MAPK3CYP3A4 | |
| SCHEMBL30554352 | 0.86 | MAPK1 (0.53) | MAPK1MAPK3CYP3A4 | |
| SCHEMBL20931540 | 0.85 | MAPK1 (0.47) | MAPK1MAPK3 | |
| SCHEMBL20931539 | 0.85 | MAPK1 (0.47) | MAPK1MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112020357-B | Salt of indazolyl-containing tricyclic derivative and crystal form thereof | 上海翰森生物医药科技有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-110546150-B | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-112020357-A | Salts of indazolyl-containing tricyclic derivatives and crystal forms thereof | 上海翰森生物医药科技有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-110546150-A | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD | 2019-12-06 | — | — | CN | disclosed |