Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.44 |
| ▸ | BCDIN3D | Q7Z5W3 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27016733 | 1.00 | TAAR1 (0.46) | TAAR1KCNN4BCDIN3DSLC6A2TACR1 | |
| SCHEMBL2903242 | 0.84 | KCNN4 (0.46) | TAAR1KCNN4SLC6A2MAPK1MAPT | |
| SCHEMBL8028843 | 0.81 | TAAR1 (0.56) | TAAR1KCNN4MAPK1MAPTLMNA | |
| SCHEMBL13141207 | 0.81 | TAAR1 (0.42) | TAAR1KCNN4SLC6A2TACR1KMT2A | |
| SCHEMBL2173457 | 0.79 | KIF11 (0.43) | TAAR1MAPK1KMT2AKIF11 | |
| SCHEMBL10145455 | 0.79 | KCNN4 (0.46) | TAAR1KCNN4MAPK1MAPTLMNA | |
| SCHEMBL155932 | 0.78 | TAAR1 (0.52) | TAAR1KCNN4SLC6A2TACR1MAPK1 | |
| SCHEMBL12393357 | 0.78 | MAPT (0.46) | TAAR1KCNN4MAPK1MAPTLMNA | |
| SCHEMBL11431197 | 0.77 | TAAR1 (0.52) | TAAR1KCNN4SLC6A2TACR1CYP2D6 | |
| SCHEMBL18663438 | 0.77 | KCNN4 (0.41) | TAAR1KCNN4SLC6A2MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110546150-B | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-110546150-A | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD | 2019-12-06 | — | — | CN | disclosed |