SCHEMBL28333388

SCHEMBL28333388

O=C(O)C=Cc1ccc(C(=O)NCCNc2c3c(nc4ccccc24)CCCC3)cc1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACHE P22303 7/20 0.73
BCHE P06276 5/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28335996 1.00 ACHE (0.73) ACHEBCHE
SCHEMBL28333406 0.94 ACHE (0.74) ACHEBCHE
SCHEMBL28333391 0.94 ACHE (0.73) ACHEBCHE
SCHEMBL28333377 0.93 ACHE (0.70) ACHEBCHE
SCHEMBL28333375 0.93 ACHE (0.70) ACHEBCHE
SCHEMBL28333361 0.87 ACHE (0.71) ACHEBCHE
SCHEMBL28333365 0.87 ACHE (0.71) ACHEBCHE
SCHEMBL28333382 0.87 ACHE (0.71) ACHEBCHE
SCHEMBL28333381 0.87 ACHE (0.71) ACHEBCHE
SCHEMBL28879572 0.84 BCHE (0.72) ACHEBCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110551067-B Multi-target tacrine derivative and preparation method and application thereof 山东大学 2020-09-08 CN disclosed
CN-110551067-A Multi-target tacrine derivative and preparation method and application thereof UNIV SHANDONG 2019-12-10 CN disclosed