Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 18/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15522088 | 0.99 | HSP90AB1 (0.51) | HSP90AB1HSP90AA1ADRB1HSP90B1TRAP1 | |
| SCHEMBL4783606 | 0.89 | HSP90AB1 (0.54) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4743235 | 0.87 | HSP90AB1 (0.53) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| Piperazine SCHEMBL28333614 | 0.86 | HSP90AA1 (0.46) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4280050 | 0.86 | HSP90AA1 (0.54) | HSP90AB1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL4787022 | 0.86 | HSP90AB1 (0.52) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL28333664 | 0.85 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1 | |
| SCHEMBL30368851 | 0.85 | HSP90AA1 (0.47) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL15522473 | 0.85 | HSP90AA1 (0.47) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4744640 | 0.84 | HSP90AA1 (0.53) | HSP90AB1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104470941-B | targeted therapeutics | 马德里加尔制药公司 | 2019-09-27 | — | — | CN | disclosed |