Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783606 | 0.89 | HSP90AB1 (0.54) | HSP90AA1HSP90AB1 | |
| SCHEMBL4743235 | 0.87 | HSP90AB1 (0.53) | HSP90AA1HSP90AB1 | |
| SCHEMBL4280050 | 0.86 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1USP2 | |
| Hydrochloric Acid SCHEMBL4787022 | 0.86 | HSP90AB1 (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL15522088 | 0.85 | HSP90AB1 (0.51) | HSP90AA1HSP90AB1 | |
| SCHEMBL22354463 | 0.84 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1 | |
| SCHEMBL20879133 | 0.84 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1 | |
| SCHEMBL22541132 | 0.84 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1 | |
| Piperazine SCHEMBL28333641 | 0.84 | HSP90AB1 (0.50) | HSP90AA1HSP90AB1 | |
| SCHEMBL15525673 | 0.83 | HSP90AB1 (0.49) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008103353-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-08-28 | — | — | WO | claimed |
| WO-2008103353-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-08-28 | — | — | WO | disclosed |