Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17784852 | 0.90 | KLKB1 (0.67) | KLKB1 | |
| SCHEMBL17786796 | 0.85 | KLKB1 (0.55) | KLKB1 | |
| SCHEMBL21190225 | 0.85 | KLKB1 (0.55) | KLKB1 | |
| SCHEMBL31314351 | 0.85 | KLKB1 (0.52) | KLKB1 | |
| SCHEMBL21145617 | 0.83 | KLKB1 (0.64) | KLKB1 | |
| SCHEMBL21985437 | 0.82 | KLKB1 (0.67) | KLKB1 | |
| SCHEMBL17784845 | 0.81 | KLKB1 (0.78) | KLKB1 | |
| SCHEMBL29365582 | 0.81 | KLKB1 (0.70) | KLKB1 | |
| SCHEMBL28277692 | 0.81 | KLKB1 (0.55) | KLKB1 | |
| SCHEMBL21190114 | 0.79 | KLKB1 (0.57) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113387933-A | Pyrazole derivatives as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-109311847-B | Pyrazole derivatives as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-107108576-B | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2020-03-10 | — | — | CN | disclosed |
| CN-110577519-A | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2019-12-17 | — | — | CN | disclosed |