Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28337382 | 0.85 | ELANE (0.32) | ELANE | |
| SCHEMBL28337392 | 0.78 | CSF1R (0.45) | ELANEPDE4AKCNH2 | |
| SCHEMBL21906312 | 0.77 | CSF1R (0.43) | ELANEPDE4AKCNH2 | |
| SCHEMBL28465215 | 0.72 | ELANE (0.43) | ELANE | |
| SCHEMBL21873056 | 0.69 | CSF1R (0.44) | ELANE | |
| SCHEMBL28466951 | 0.69 | ELANE (0.41) | ELANEKCNH2 | |
| SCHEMBL21872988 | 0.68 | CSF1R (0.42) | ELANEPDE4AKCNH2 | |
| SCHEMBL28462480 | 0.63 | ELANE (0.44) | ELANE | |
| SCHEMBL11027996 | 0.63 | ELANE (0.48) | ELANE | |
| SCHEMBL30069016 | 0.62 | ELANE (0.49) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110461841-B | Nitrogen heteroaryl derivative with CSF1R inhibitory activity, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-09-15 | — | — | CN | disclosed |
| CN-110461841-A | A kind of azepine aryl derivatives, preparation method and application with CSF1R inhibitory activity | ABBISKO THERAPEUTICS CO LTD | 2019-11-15 | — | — | CN | disclosed |