Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 12/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21873056 | 0.90 | CSF1R (0.44) | CSF1RPDGFRAPDGFRBKDRELANE | |
| SCHEMBL21906312 | 0.85 | CSF1R (0.43) | CSF1RPDGFRAPDGFRBKDRELANE | |
| SCHEMBL21873140 | 0.81 | GPR84 (0.46) | CSF1RPDGFRAPDGFRBKDRKDM4E | |
| SCHEMBL28337393 | 0.78 | ELANE (0.33) | ELANEPDE4AKCNH2 | |
| SCHEMBL21872988 | 0.76 | CSF1R (0.42) | CSF1RPDGFRAPDGFRBKDRELANE | |
| SCHEMBL28337382 | 0.74 | ELANE (0.32) | ELANE | |
| SCHEMBL28465215 | 0.73 | ELANE (0.43) | ELANEKDM4EALDH1A1CES2HDAC3 | |
| SCHEMBL21906344 | 0.73 | CSF1R (0.45) | CSF1RPDGFRAPDGFRBKDRKDM4E | |
| SCHEMBL21873148 | 0.73 | CSF1R (0.44) | CSF1RPDGFRAPDGFRBKDRFLT3 | |
| SCHEMBL21872995 | 0.72 | CSF1R (0.48) | CSF1RPDGFRAPDGFRBKDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110461841-B | Nitrogen heteroaryl derivative with CSF1R inhibitory activity, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-09-15 | — | — | CN | disclosed |
| CN-110461841-A | A kind of azepine aryl derivatives, preparation method and application with CSF1R inhibitory activity | ABBISKO THERAPEUTICS CO LTD | 2019-11-15 | — | — | CN | disclosed |