Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21873011 | 0.87 | HSP90AA1 (0.35) | TBXA2R | |
| SCHEMBL21872998 | 0.75 | JAK2 (0.42) | CYP2C9BRD4FGFR1 | |
| SCHEMBL17873361 | 0.66 | TBXA2R (0.34) | CYP2C9PKMYT1TBXA2RLMNAHPGD | |
| SCHEMBL30491288 | 0.65 | ELANE (0.44) | — | |
| SCHEMBL29524409 | 0.63 | GABRP (0.66) | HPGDMAPK1MEN1KMT2ANPC1 | |
| SCHEMBL398966 | 0.63 | GABRP (0.66) | HPGDMAPK1MEN1KMT2ANPC1 | |
| SCHEMBL22135883 | 0.63 | HPGD (0.41) | CYP2C9PKMYT1LMNAMAPTHPGD | |
| SCHEMBL17873380 | 0.62 | CYP2A6 (0.33) | LMNAHPGDMEN1KMT2A | |
| SCHEMBL12410963 | 0.60 | SMN1; SMN2 (0.54) | LMNAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL403869 | 0.60 | GABRP (0.46) | MAPTMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110461841-B | Nitrogen heteroaryl derivative with CSF1R inhibitory activity, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-09-15 | — | — | CN | disclosed |
| CN-110461841-A | A kind of azepine aryl derivatives, preparation method and application with CSF1R inhibitory activity | ABBISKO THERAPEUTICS CO LTD | 2019-11-15 | — | — | CN | disclosed |