Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FER | P16591 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11012661 | 0.81 | CREBBP (0.54) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL11451121 | 0.76 | CREBBP (0.50) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL30122758 | 0.76 | MAOA (0.45) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL1074137 | 0.76 | LRRK2 (0.45) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL30556308 | 0.76 | MAOA (0.41) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL5144419 | 0.75 | IDO1 (0.50) | BRPF1CREBBPALDH1A1L3MBTL1GSK3B | |
| SCHEMBL30364585 | 0.75 | IDO1 (0.50) | BRPF1CREBBPALDH1A1L3MBTL1GSK3B | |
| SCHEMBL9393278 | 0.74 | MEN1 (0.59) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL13685637 | 0.73 | MAPT (0.59) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL14375245 | 0.72 | PIM1 (0.60) | LRRK2MAOAMAOBPDGFRAFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110582291-A | Reactivity marker and efficacy-improving modulator for anti-PD 1/PD-L1/PD-L2 antibody | 古斯达威罗斯研究所 | 2019-12-17 | — | — | CN | disclosed |