Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL202058 | 0.81 | KDM4E (0.49) | KDM4EPOLBCTDSP1TDP1L3MBTL1 | |
| SCHEMBL31685091 | 0.79 | L3MBTL1 (0.47) | KDM4EPOLBCTDSP1TDP1L3MBTL1 | |
| SCHEMBL27295534 | 0.79 | L3MBTL1 (0.47) | KDM4EPOLBCTDSP1TDP1L3MBTL1 | |
| SCHEMBL202632 | 0.78 | POLB (0.46) | KDM4EPOLBCTDSP1TDP1L3MBTL1 | |
| SCHEMBL3419883 | 0.76 | TDP1 (0.51) | KDM4EPOLBCTDSP1TDP1L3MBTL1 | |
| SCHEMBL5356037 | 0.76 | KDM4E (0.51) | KDM4EPOLBCTDSP1TDP1L3MBTL1 | |
| SCHEMBL4921124 | 0.74 | CA12 (0.55) | KDM4EPOLBCTDSP1TDP1L3MBTL1 | |
| SCHEMBL29849387 | 0.74 | CA12 (0.55) | KDM4EPOLBCTDSP1TDP1L3MBTL1 | |
| SCHEMBL17785291 | 0.72 | HTR2A (0.42) | KDM4ELMNAHTTMAPK1RAB9A | |
| SCHEMBL18374606 | 0.70 | TUBB1 (0.36) | KDM4ETDP1LMNAHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113387933-A | Pyrazole derivatives as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-109311847-B | Pyrazole derivatives as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-107108576-B | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2020-03-10 | — | — | CN | disclosed |
| CN-110577519-A | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2019-12-17 | — | — | CN | disclosed |