Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28339340 | 1.00 | AURKA (0.35) | AURKAMAPTP2RY12ACHEBACE1 | |
| SCHEMBL28337228 | 0.91 | MAPT (0.33) | AURKAMAPTP2RY12ACHEBACE1 | |
| SCHEMBL15390831 | 0.88 | KIT (0.41) | MAPTACHEKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL15390832 | 0.88 | KIT (0.41) | MAPTACHEKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL16719272 | 0.87 | AURKA (0.31) | AURKAMAPT | |
| SCHEMBL30142914 | 0.87 | CLK4 (0.36) | MAPTTSHRENPP1ALDH1A1HPGD | |
| SCHEMBL16773148 | 0.86 | AURKA (0.30) | AURKA | |
| SCHEMBL21485105 | 0.84 | LIMK2 (0.35) | AURKA | |
| SCHEMBL21485106 | 0.84 | LIMK2 (0.35) | AURKA | |
| SCHEMBL16784356 | 0.78 | KIT (0.43) | MAPTACHEKMT2ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590606-B | Process for preparing pyrimidylcyclopentane compounds | 豪夫迈·罗氏有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-105899492-B | Process for preparing pyrimidylcyclopentane compounds | 豪夫迈·罗氏有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-112898210-A | Process for preparing pyrimidylcyclopentane compounds | 豪夫迈·罗氏有限公司 | 2021-06-04 | — | — | CN | disclosed |
| CN-110590606-A | Process for preparing pyrimidylcyclopentane compounds | 豪夫迈·罗氏有限公司 | 2019-12-20 | — | — | CN | disclosed |