⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21906297 | 0.76 | CSF1R (0.43) | — | |
| SCHEMBL21906344 | 0.76 | CSF1R (0.45) | — | |
| SCHEMBL21906323 | 0.74 | IDH1 (0.33) | — | |
| SCHEMBL21873038 | 0.68 | CSF1R (0.43) | — | |
| SCHEMBL21873001 | 0.67 | CSF1R (0.44) | — | |
| SCHEMBL21872990 | 0.66 | AAK1 (0.32) | — | |
| SCHEMBL21873122 | 0.59 | CSF1R (0.44) | — | |
| SCHEMBL21873024 | 0.58 | CSF1R (0.44) | — | |
| SCHEMBL28338103 | 0.55 | CYP2C9 (0.31) | — | |
| SCHEMBL30491288 | 0.55 | ELANE (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110461841-B | Nitrogen heteroaryl derivative with CSF1R inhibitory activity, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-09-15 | — | — | CN | disclosed |
| CN-110461841-A | A kind of azepine aryl derivatives, preparation method and application with CSF1R inhibitory activity | ABBISKO THERAPEUTICS CO LTD | 2019-11-15 | — | — | CN | disclosed |