Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 6/20 | 0.33 |
| ▸ | CDK9 | P50750 | 5/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.33 |
| ▸ | CDC7 | O00311 | 5/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | PRKACA | P17612 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21872992 | 0.88 | CSF1R (0.44) | CSF1RPDGFRBPDGFRAFLT3LCK | |
| SCHEMBL21873003 | 0.80 | GPR84 (0.45) | CSF1RPDGFRBPDGFRAFLT3LCK | |
| SCHEMBL21977192 | 0.79 | CSF1R (0.43) | CSF1RPDGFRBPDGFRAFLT3LCK | |
| SCHEMBL21965132 | 0.79 | CSF1R (0.42) | CSF1RPDGFRBPDGFRAFLT3LCK | |
| SCHEMBL21873122 | 0.77 | CSF1R (0.44) | CSF1RPDGFRBPDGFRAFLT3LCK | |
| SCHEMBL21873037 | 0.76 | CSF1R (0.43) | CSF1RPDGFRBPDGFRAFLT3LCK | |
| SCHEMBL21873007 | 0.72 | MAP2K1 (0.43) | FLT3METCDK2CDK9CDC7 | |
| SCHEMBL30825676 | 0.71 | CSF1R (0.54) | CSF1RPDGFRBPDGFRAFLT3LCK | |
| SCHEMBL29222872 | 0.71 | CSF1R (0.54) | CSF1RPDGFRBPDGFRAFLT3LCK | |
| SCHEMBL21872975 | 0.71 | CCNB2 (0.38) | CSF1RFLT3METCDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110461841-A | A kind of azepine aryl derivatives, preparation method and application with CSF1R inhibitory activity | ABBISKO THERAPEUTICS CO LTD | 2019-11-15 | — | — | CN | disclosed |