Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2681713 | 0.89 | DDB1 (0.52) | DDB1CRBNGPR119CCNCCDK8 | |
| SCHEMBL3599876 | 0.82 | NR1H2 (0.38) | GPR119USP30NR1H2RORC | |
| SCHEMBL15647731 | 0.79 | ROCK2 (0.39) | DDB1CRBNGPR119USP30NR1H2 | |
| SCHEMBL660078 | 0.79 | USP30 (0.49) | DDB1CRBNGPR119USP30NR1H2 | |
| SCHEMBL991994 | 0.78 | DDB1 (0.38) | DDB1CRBNGPR119CCNCCDK8 | |
| SCHEMBL25326690 | 0.78 | DDB1 (0.43) | DDB1CRBNPSEN1PSEN2APH1B | |
| SCHEMBL11946807 | 0.78 | DDB1 (0.43) | DDB1CRBNPSEN1PSEN2APH1B | |
| SCHEMBL24990092 | 0.77 | DDB1 (0.43) | DDB1CRBNGPR119USP30NR1H2 | |
| SCHEMBL22585504 | 0.77 | DDB1 (0.43) | DDB1CRBNPSEN1PSEN2APH1B | |
| SCHEMBL23511226 | 0.77 | DDB1 (0.43) | DDB1CRBNPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110627770-A | Tetrahydroquinoline compositions as BET bromodomain inhibitors | 福马疗法公司 | 2019-12-31 | — | — | CN | disclosed |