Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 8/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28199979 | 0.74 | KDM4E (0.38) | KDM4EMAP2K1MAP2K2BRD4BRD9 | |
| SCHEMBL12677164 | 0.73 | BRD4 (0.42) | KDM4EMAP2K1MAP2K2BRD4BRD9 | |
| SCHEMBL28346481 | 0.72 | MAP2K1 (0.40) | KDM4EMAP2K1MAP2K2BRD4BRD9 | |
| SCHEMBL20516021 | 0.70 | BRD4 (0.41) | KDM4EMAP2K1MAP2K2BRD4BRD9 | |
| SCHEMBL10341192 | 0.68 | KDM4E (0.49) | KDM4EMAP2K1MAP2K2ALDH1A1HPGD | |
| SCHEMBL29812644 | 0.68 | MAP2K1 (0.41) | KDM4EMAP2K1MAP2K2BRD4BRD9 | |
| SCHEMBL28341822 | 0.68 | CCNC (0.47) | KDM4EMAP2K1MAP2K2BRD4BRD9 | |
| SCHEMBL19332543 | 0.68 | MAPT (0.40) | KDM4EPARP1L3MBTL1ALDH1A1GAA | |
| SCHEMBL9836198 | 0.67 | KDM4E (0.39) | KDM4EMAP2K1MAP2K2BRD4BRD9 | |
| SCHEMBL30542063 | 0.67 | KDM4E (0.71) | KDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110520416-B | Polysubstituted pyridone derivative, preparation method and medical application thereof | 北京越之康泰生物医药科技有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-110520416-A | Polysubstituted pyridine ketones derivant, preparation method and its medical usage | BEIJING YUEZHIKANGTAI BIOMEDICINES CO LTD | 2019-11-29 | — | — | CN | disclosed |