⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206030 | 1.00 | — | — | |
| SCHEMBL10469226 | 1.00 | — | — | |
| SCHEMBL1254916 | 0.83 | LPO (0.43) | — | |
| SCHEMBL19999314 | 0.81 | — | — | |
| SCHEMBL4256486 | 0.78 | LPO (0.39) | — | |
| SCHEMBL4259643 | 0.78 | LPO (0.39) | — | |
| SCHEMBL213036 | 0.76 | LPO (0.38) | — | |
| SCHEMBL213035 | 0.76 | LPO (0.38) | — | |
| SCHEMBL12483005 | 0.76 | PTP4A3 (0.39) | — | |
| SCHEMBL15871029 | 0.75 | LPO (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110088104-B | Tetrahydropyridopyrimidine compounds for the treatment and prevention of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2022-04-12 | — | — | CN | disclosed |
| US-10968218-B2 | Tetrahydropyridopyrimidines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2021-04-06 | — | — | US | disclosed |
| EP-3535261-B1 | NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2020-08-05 | — | — | EP | disclosed |
| US-20200062748-A1 | NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2020-02-27 | — | — | US | disclosed |
| EP-3535261-A1 | NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2019-09-11 | — | — | EP | disclosed |
| US-20100303725-A1 | Technetium- and Rhenium-Bis(heteroaryl) Complexes, and Methods of Use Thereof | MOLECULAR INSIGHT PHARMACEUTICALS, INC. | 2010-12-02 | — | — | US | disclosed |
| US-7824661-B2 | Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| EP-1718342-A4 | TECHNETIUM-AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF | MOLECULAR INSIGHT PHARM INC (US) | 2009-07-22 | — | — | EP | disclosed |
| EP-1713515-A4 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF | MOLECULAR INSIGHT PHARM INC (US) | 2009-07-22 | — | — | EP | disclosed |
| US-20090148382-A1 | Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof | MOLECULAR INSIGHT PHARMACEUTICALS, INC. | 2009-06-11 | — | — | US | disclosed |
| EP-1585743-B1 | 2-(1H-INDAZOL-6-YLAMINO)- BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTHALMIC DISEASES | PFIZER (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1718342-A1 | TECHNETIUM-AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF | Molecular Insight Pharmaceuticals, Inc. (US) | 2006-11-08 | — | — | EP | disclosed |
| EP-1713515-A1 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF | Molecular Insight Pharmaceuticals, Inc. (US) | 2006-10-25 | — | — | EP | disclosed |
| US-20060160858-A1 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS INC. | 2006-07-20 | — | — | US | disclosed |
| US-7053107-B2 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20060093552-A1 | Technetium-and rhenium-bis(heteroaryl) complexes, and methods of use thereof | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2006-05-04 | — | — | US | disclosed |
| US-20060034758-A1 | Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2006-02-16 | — | — | US | disclosed |
| WO-2005079865-A1 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF | MOLECULAR INSIGHT PHARMACEUTICALS (US) | 2005-09-01 | — | — | WO | disclosed |
| WO-2005079866-A1 | TECHNETIUM-AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF | MOLECULAR INSIGHT PHARMACEUTICALS (US) | 2005-09-01 | — | — | WO | disclosed |
| US-20040192735-A1 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2004-09-30 | — | — | US | disclosed |