LPO — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Carbimazole (SCHEMBL44211)	1.00	9/20
Carbimazole (SCHEMBL3137059)	0.96	9/20
SCHEMBL24244797	0.63	8/20
SCHEMBL972118	0.55	8/20
SCHEMBL26311540	0.59	7/20
SCHEMBL26295022	0.57	7/20
Carbimazole (SCHEMBL20771744)	0.66	6/20
SCHEMBL9387299	0.52	6/20
SCHEMBL9248493	0.52	6/20
SCHEMBL21105700	0.57	5/20
SCHEMBL3172693	0.55	5/20
SCHEMBL19411131	0.52	4/20
SCHEMBL19411213	0.52	4/20
SCHEMBL587358	0.50	4/20
SCHEMBL7548705	0.50	4/20
SCHEMBL15284133	0.50	4/20
SCHEMBL600415	0.44	4/20
SCHEMBL10511129	0.44	4/20
Hydrochloric Acid (SCHEMBL7492690)	0.41	4/20
SCHEMBL2118407	0.41	4/20

Clinical trials — most relevant to LPO by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus	PHASE4	COMPLETED
Supplementation With Lactoferrin in Preterm Newborns	PHASE4	COMPLETED
Role of Antioxidants Supplementation in Chronic Pancreatitis	PHASE3	COMPLETED
Lactoferrin Versus Ferrous Sulfate in Management of Iron Deficiency Anemia Among Female Medical Ain Shams Students	PHASE2/PHASE3	COMPLETED
Beneficial Effect of Silymarin in Ulcerative Colitis	PHASE2	RECRUITING
Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis.	PHASE2	COMPLETED
Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis	PHASE1/PHASE2	COMPLETED
The Adjunctive Use of Melatonin Therapy in the Treatment of Obese Periodontitis Patients (Clinical and Immunological Study).	PHASE1/PHASE2	UNKNOWN
Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS	PHASE2	RECRUITING
A Supervised Nutritional Program in Pregnancies and NF-κB Expression in Placenta	PHASE1	COMPLETED
The Effect of Manual Lymph Drainage in Fibromyalgia Patients	EARLY_PHASE1	ENROLLING_BY_INVITATION
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Natural Enzyme Mouthwash After Third Molar Surgery	nan	COMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Personalizing Preterm Neonatal Transfusions With Fetal Hemoglobin-Enriched Cord Blood	nan	NOT_YET_RECRUITING
The Sublimated Mare Milk Supplement's Effect on Gut Mucosal Lining After Antibiotics	nan	COMPLETED
Effects of Green Tea Extract (GTE) on Systemic Oxidative and Antioxidative Status in Chinese Patients With Stable Asthma	nan	COMPLETED
Glycoxidation, Arterial Biomechanics, and Target Organ Damage	nan	RECRUITING
Investigating Lipid Peroxidation Products in Donor Human Milk	nan	COMPLETED
Effect of Resveratrol and Vitamin C on Insulin Resistance Among Postmenopausal Women	nan	UNKNOWN
The Hilo Pilot -Trial to Assess Feasibility	nan	COMPLETED
Chocolate for Patients With Chronic Kidney Disease	nan	COMPLETED
Role of USP35 in the Detection of Ferroptosis in Juvenile Autoimmune Hepatitis	nan	NOT_YET_RECRUITING
30% or 60% Oxygen at Birth to Improve Neurodevelopmental Outcomes in Very Low Birthweight Infants	nan	RECRUITING
Paraoxonase and HDL Qualities in Glycaemia and Inflammation	nan	RECRUITING
Serum Oxidative Status as a Potential Predictor of Coronary Artery Disease.	nan	UNKNOWN
Covid-19: Possible Role of Neutrophil Extracellular Traps	nan	UNKNOWN
The Effect of Aerobic and Anaerobic Exercise on Oxidative Stress and Cellular Fitness in Healthy Trained Young Men	nan	ENROLLING_BY_INVITATION
Consumption of Apple Juice in Hemodialysis Patients	nan	COMPLETED
Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LPO binder may also engage these)

Protein	Name	Similarity
A0A452E9Y6	—	1.000	A0A452E9Y6 →
Q5SW46	—	1.000	Q5SW46 →
Q8R481	—	1.000	Q8R481 →
P80025	—	1.000	P80025 →
A5JUY8	—	1.000	A5JUY8 →
P35419	—	0.996	P35419 →
P14650	—	0.994	P14650 →
TPO	Thyroid peroxidase	0.991	landscape →
Q9VEG6	—	0.987	Q9VEG6 →
P82600	—	0.985	P82600 →
Q23490	—	0.981	Q23490 →
F5HM55	—	0.980	F5HM55 →
A0A1Y9G8H0	—	0.978	A0A1Y9G8H0 →
Q01603	—	0.976	Q01603 →
P09933	—	0.976	P09933 →
Q7QH73	—	0.976	Q7QH73 →
Q1ENI8	—	0.975	Q1ENI8 →
Q8HYB7	—	0.975	Q8HYB7 →
A8WQH2	—	0.973	A8WQH2 →
Q9VQH2	—	0.972	Q9VQH2 →
Q6TMK4	—	0.972	Q6TMK4 →
O62664	—	0.971	O62664 →
Q8HZR1	—	0.971	Q8HZR1 →
O61213	—	0.970	O61213 →
Q20616	—	0.969	Q20616 →
O97554	—	0.969	O97554 →
Q9ES45	—	0.968	Q9ES45 →
Q05769	—	0.968	Q05769 →
G5EG78	—	0.968	G5EG78 →
P27607	—	0.967	P27607 →