SCHEMBL28344779

SCHEMBL28344779

C=Cc1ccc(C(C)(C)C)cc1.ClC=Cc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
TSHR P16473 1/20 0.47
TRPV1 Q8NER1 2/20 0.43
CYP1A2 P05177 1/20 0.42
POLB P06746 1/20 0.41
HTT P42858 1/20 0.41
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
ESRRG P62508 1/20 0.37
CYP2C19 P33261 1/20 0.37
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
LMNA P02545 1/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
TNIK Q9UKE5 1/20 0.35
MAPT P10636 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL7512832 0.88 ALDH1A1 (0.61) ALDH1A1TSHRTRPV1CYP1A2NR1H2
SCHEMBL5568864 0.85 ALDH1A1 (0.48) ALDH1A1TSHRTRPV1CYP1A2POLB
SCHEMBL277827 0.84 CYP1A2 (0.55) ALDH1A1TSHRTRPV1CYP1A2POLB
Styrene SCHEMBL185432 0.84 ALDH1A1 (0.67) ALDH1A1TSHRCYP1A2POLBNPC1
SCHEMBL6884409 0.82 CYP1A2 (0.53) ALDH1A1TSHRTRPV1CYP1A2POLB
SCHEMBL6876844 0.82 CYP1A2 (0.53) ALDH1A1TSHRTRPV1CYP1A2POLB
SCHEMBL11145302 0.81 ALDH1A1 (0.52) ALDH1A1TSHRCYP1A2CYP2C19NPC1
Styrene SCHEMBL27540459 0.81 ALDH1A1 (0.52) ALDH1A1TSHRCYP1A2CYP2C19NPC1
SCHEMBL7049965 0.81 ALDH1A1 (0.52) ALDH1A1TSHRCYP1A2CYP2C19NPC1
Benzene SCHEMBL8586542 0.80 ALDH1A1 (0.48) ALDH1A1TSHRTRPV1CYP1A2ESRRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105278240-B Method of making block copolymers and articles made therefrom 陶氏环球技术有限责任公司 2019-12-10 CN disclosed