Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.74 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.67 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 3/20 | 0.61 |
| ▸ | INSR | P06213 | 3/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.61 |
| ▸ | CDK2 | P24941 | 3/20 | 0.61 |
| ▸ | PLK1 | P53350 | 3/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2698774 | 0.90 | EGFR (0.74) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL2700695 | 0.88 | EGFR (0.68) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL217090 | 0.88 | EGFR (0.68) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL14509726 | 0.87 | EGFR (0.75) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL2510931 | 0.87 | EGFR (0.75) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL233913 | 0.87 | EGFR (0.77) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL2505296 | 0.87 | EGFR (0.77) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL9973598 | 0.86 | EGFR (0.73) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL141514 | 0.86 | EGFR (0.73) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL14878664 | 0.86 | EGFR (0.79) | EGFRERBB2GAKERBB4ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110698417-B | Preparation method of 6-substituent furyl-4-substituted amino quinazoline derivative and key intermediate thereof | 新发药业有限公司 | 2020-11-20 | — | — | CN | claimed |
| CN-110698417-A | Preparation method of 6-substituent furyl-4-substituted amino quinazoline derivative and key intermediate thereof | 新发药业有限公司 | 2020-01-17 | — | — | CN | claimed |
| CN-110698417-B | Preparation method of 6-substituent furyl-4-substituted amino quinazoline derivative and key intermediate thereof | 新发药业有限公司 | 2020-11-20 | — | — | CN | disclosed |
| CN-110698417-B | Preparation method of 6-substituent furyl-4-substituted amino quinazoline derivative and key intermediate thereof | 新发药业有限公司 | 2020-11-20 | — | — | CN | disclosed |
| CN-110698417-A | Preparation method of 6-substituent furyl-4-substituted amino quinazoline derivative and key intermediate thereof | 新发药业有限公司 | 2020-01-17 | — | — | CN | disclosed |
| CN-110698417-A | Preparation method of 6-substituent furyl-4-substituted amino quinazoline derivative and key intermediate thereof | 新发药业有限公司 | 2020-01-17 | — | — | CN | disclosed |