Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 10/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28344737 | 0.88 | HIF1A (1.00) | HIF1AMEN1KMT2AKCNH2SCN5A | |
| SCHEMBL28348304 | 0.87 | HIF1A (0.81) | HIF1AMEN1KMT2ANPC1RAB9A | |
| SCHEMBL28347976 | 0.84 | HIF1A (0.84) | HIF1AMEN1KMT2AKCNH2SCN5A | |
| SCHEMBL28345384 | 0.84 | HIF1A (0.88) | HIF1AMEN1KMT2AKCNH2SCN5A | |
| SCHEMBL28598211 | 0.83 | HIF1A (1.00) | HIF1AMEN1KMT2ANPC1RAB9A | |
| SCHEMBL28344653 | 0.82 | HIF1A (0.73) | HIF1ATP53ROCK2NPC1RAB9A | |
| SCHEMBL28348077 | 0.81 | HIF1A (0.86) | HIF1AMEN1KMT2AKCNH2SCN5A | |
| SCHEMBL28345377 | 0.81 | HIF1A (1.00) | HIF1AMEN1KMT2AKCNH2SCN5A | |
| SCHEMBL28594259 | 0.80 | HIF1A (0.84) | HIF1AMEN1KMT2ANPC1RAB9A | |
| SCHEMBL28608102 | 0.80 | HIF1A (0.76) | HIF1AMEN1KMT2AROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110407824-B | Aryl formamide compound and preparation method, pharmaceutical composition and application thereof | 安徽医科大学 | 2021-07-02 | — | — | CN | disclosed |
| CN-112426422-A | Application of pyridine carboxamide derivative AMSP-30m in preparation of drugs for preventing and treating rheumatoid arthritis | 安徽医科大学 | 2021-03-02 | — | — | CN | disclosed |
| CN-110407824-A | Aryl methanamide compounds and preparation method thereof, pharmaceutical composition and purposes | UNIV ANHUI MEDICAL | 2019-11-05 | — | — | CN | disclosed |