Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Kaempferol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 known ✓ | P30518 | 1/20 | 0.69 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.69 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.86 |
| ▸ | MEN1 | O00255 | 8/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.86 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.86 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.86 |
| ▸ | FTO | Q9C0B1 | 6/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.86 |
| ▸ | XDH | P47989 | 6/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.86 |
| ▸ | MAPT | P10636 | 5/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.86 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.86 |
| ▸ | APP | P05067 | 5/20 | 0.86 |
| ▸ | BCHE | P06276 | 4/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Kaempferol SCHEMBL30655455 | 0.93 | MEN1 (1.00) | ABCB1CYP1A2MEN1KMT2ACYP1A1 | |
| Kaempferol SCHEMBL1259228 | 0.93 | MEN1 (1.00) | ABCB1CYP1A2MEN1KMT2ACYP1A1 | |
| Kaempferol SCHEMBL18817 | 0.93 | MEN1 (1.00) | ABCB1CYP1A2MEN1KMT2ACYP1A1 | |
| Kaempferol SCHEMBL29378805 | 0.93 | MEN1 (1.00) | ABCB1CYP1A2MEN1KMT2ACYP1A1 | |
| Kaempferol SCHEMBL38651062 | 0.92 | MEN1 (0.97) | ABCB1CYP1A2MEN1KMT2ACYP1A1 | |
| Kaempferol SCHEMBL31256029 | 0.92 | MEN1 (0.97) | ABCB1CYP1A2MEN1KMT2ACYP1A1 | |
| Kaempferol SCHEMBL31749037 | 0.92 | MEN1 (0.97) | ABCB1CYP1A2MEN1KMT2ACYP1A1 | |
| Kaempferol SCHEMBL34461912 | 0.92 | MEN1 (0.97) | ABCB1CYP1A2MEN1KMT2ACYP1A1 | |
| Kaempferol SCHEMBL31577746 | 0.92 | MEN1 (0.97) | ABCB1CYP1A2MEN1KMT2ACYP1A1 | |
| Kaempferol SCHEMBL17237761 | 0.92 | MEN1 (0.97) | ABCB1CYP1A2MEN1KMT2ACYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110604762-A | Traditional Chinese medicine composition for treating kidney-type infectious bronchitis of poultry and preparation method thereof | 临沂金翠兽药有限公司 | 2019-12-24 | — | — | CN | disclosed |