Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3754787 | 0.86 | SMN1; SMN2 (0.63) | NPC1RAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL9725165 | 0.84 | SMN1; SMN2 (0.44) | NPC1RAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL10650999 | 0.84 | MEN1 (0.51) | NPC1RAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL16568339 | 0.84 | MAOA (0.64) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL7641652 | 0.79 | MEN1 (0.59) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL11056635 | 0.79 | SMN1; SMN2 (0.74) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL3070329 | 0.78 | KMT2A (0.76) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL3932390 | 0.75 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL26333583 | 0.75 | MEN1 (0.60) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL3996276 | 0.74 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573518-A | Substituted bicyclic pyrimidinyl compounds, compositions and uses thereof | 尤拉·S·赞特里佐斯 | 2019-12-13 | — | — | CN | disclosed |