Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.32 |
| ▸ | CDK2 | P24941 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28348910 | 0.83 | THRB (0.42) | DPP4EPHX1CCNE1CDK2SMN1; SMN2 | |
| SCHEMBL28457660 | 0.79 | EPHX1 (0.38) | DPP4EPHX1SMN1; SMN2NPC1HTT | |
| SCHEMBL12669754 | 0.78 | EPHX1 (0.48) | DPP4EPHX1SMN1; SMN2NTMT1LMNA | |
| SCHEMBL7812041 | 0.78 | EPHX1 (0.53) | DPP4EPHX1SMN1; SMN2NPC1HTT | |
| SCHEMBL22105022 | 0.78 | HPGD (0.32) | EPHX1 | |
| SCHEMBL25270841 | 0.77 | EPHX1 (0.39) | DPP4EPHX1CCNE1CDK2SMN1; SMN2 | |
| SCHEMBL8495444 | 0.77 | EPHX1 (0.56) | DPP4EPHX1SMN1; SMN2NPC1HTT | |
| SCHEMBL7815595 | 0.74 | EPHX1 (0.42) | DPP4EPHX1CCNE1CDK2SMN1; SMN2 | |
| SCHEMBL22105320 | 0.73 | CYP19A1 (0.31) | — | |
| SCHEMBL25277512 | 0.72 | EPHX1 (0.36) | DPP4EPHX1CCNE1CDK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105849099-B | Polycyclic inhibitors of cyclin dependent kinase 7(CDK7) | 达纳-法伯癌症研究所股份有限公司 | 2020-01-17 | — | — | CN | disclosed |