SCHEMBL28350545

SCHEMBL28350545

CCC=C(Cc1ccccc1)C(=O)Oc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.43
CYP19A1 P11511 1/20 0.43
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
GAA P10253 1/20 0.41
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
AKR1B1 P15121 1/20 0.40
HPGD P15428 2/20 0.40
KMT2A Q03164 1/20 0.40
TSHR P16473 1/20 0.39
RAB9A P51151 3/20 0.38
NPC1 O15118 1/20 0.38
POLB P06746 1/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPK1 P28482 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
USP2 O75604 1/20 0.38
CTBP2 P56545 1/20 0.38
MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9380754 0.85 ELANE (0.42) SMN1; SMN2CYP19A1HPGDKMT2ARAB9A
SCHEMBL28125867 0.85 SMN1; SMN2 (0.46) SMN1; SMN2CYP19A1CYP3A4CYP2C9GAA
SCHEMBL29117653 0.84 CYP3A4 (0.45) SMN1; SMN2CYP3A4CYP2C9CES2CES1
SCHEMBL8167540 0.80 CYP3A4 (0.41) CYP3A4CYP2C9CES2CES1AKR1B1
SCHEMBL8167538 0.80 CYP3A4 (0.41) CYP3A4CYP2C9CES2CES1AKR1B1
SCHEMBL800101 0.80 CYP3A4 (0.59) CYP3A4CYP2C9CES2CES1AKR1B1
SCHEMBL7336694 0.80 CYP3A4 (0.59) CYP3A4CYP2C9CES2CES1AKR1B1
SCHEMBL2192019 0.80 CYP3A4 (0.59) CYP3A4CYP2C9CES2CES1AKR1B1
SCHEMBL28765671 0.78 CYP3A4 (0.49) CYP3A4CYP2C9CES2CES1AKR1B1
SCHEMBL29037546 0.78 ELANE (0.40) SMN1; SMN2CYP19A1GAAKMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110668940-A Synthesis method of alpha, beta-unsaturated carboxylic ester derivative by visible light catalysis 浙江工业大学 2020-01-10 CN disclosed