Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20174129 | 0.86 | ELANE (0.45) | ELANEMAPTZDHHC2MEN1KMT2A | |
| SCHEMBL1336622 | 0.86 | ELANE (0.45) | ELANEMAPTZDHHC2MEN1KMT2A | |
| SCHEMBL28350545 | 0.85 | SMN1; SMN2 (0.43) | MAPTKMT2ARAB9AALDH1A1NPC1 | |
| SCHEMBL29037546 | 0.85 | ELANE (0.40) | ELANEMAPTZDHHC2MEN1KMT2A | |
| SCHEMBL7585128 | 0.83 | MEN1 (0.36) | ELANEMAPTMEN1KMT2ARECQL | |
| SCHEMBL28972563 | 0.83 | LMNA (0.45) | ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL28803483 | 0.83 | ELANE (0.42) | ELANEMAPTZDHHC2MEN1KMT2A | |
| SCHEMBL28348713 | 0.81 | KMT2A (0.51) | ELANEMAPTMEN1KMT2ARECQL | |
| SCHEMBL15941383 | 0.81 | ELANE (0.41) | ELANEMAPTZDHHC2MEN1KMT2A | |
| SCHEMBL432377 | 0.81 | ELANE (0.42) | ELANEMAPTZDHHC2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |