Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 9/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.73 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.73 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.73 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.73 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367030 | 0.84 | HDAC1 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7364670 | 0.82 | HDAC1 (0.70) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL15741897 | 0.82 | ALDH1A1 (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14424449 | 0.80 | HDAC1 (0.70) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1366003 | 0.80 | HDAC1 (0.77) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL15741798 | 0.80 | EPHX1 (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9187979 | 0.80 | EPHX1 (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL15741893 | 0.79 | FOLH1 (0.65) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL15741888 | 0.79 | KMT2A (0.66) | HDAC3HDAC1HDAC2HDAC6EPHX1 | |
| SCHEMBL15741900 | 0.79 | FOLH1 (0.65) | EPHX1CNR1RAB9AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644323-B1 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | UNIV GEORGETOWN (US) | 2015-03-18 | — | — | EP | disclosed |
| EP-2258677-B1 | HISTONE DEACETYLASE INHIBITORS | UNIV GEORGETOWN (US) | 2014-06-18 | — | — | EP | disclosed |
| US-20130065963-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2013-03-14 | — | — | US | disclosed |
| EP-2258677-A2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2010-12-08 | — | — | EP | disclosed |
| US-7842835-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2010-11-30 | — | — | US | disclosed |
| US-7507828-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| EP-1644323-A4 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | UNIV GEORGETOWN (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1644323-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20050032831-A1 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY | 2005-02-10 | — | — | US | disclosed |
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |
| US-20050014839-A1 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065963-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | HDAC5, HDAC6, HDAC1 | HDAC3 5/4885HDAC4 6/4885HDAC1 3/4885 |
| US-20050032831-A1 | Histone deacetylase inhibitors and methods of use thereof | HDAC5, HDAC6, HDAC1 | HDAC3 4/4885HDAC4 7/4885HDAC1 3/4885 |
| US-20050014839-A1 | Histone deacetylase inhibitors and methods of use thereof | HDAC5, HDAC6, HDAC1 | HDAC3 5/4885HDAC4 6/4885HDAC1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.