Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 1.00 |
| ▸ | MMP2 | P08253 | 7/20 | 1.00 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.71 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17871364 | 1.00 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAMTS4ADAM17 | |
| SCHEMBL17871085 | 0.90 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAMTS4ADAM17 | |
| SCHEMBL17871483 | 0.88 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAMTS4ADAM17 | |
| SCHEMBL17871544 | 0.88 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAMTS4ADAM17 | |
| SCHEMBL17871101 | 0.86 | ADAMTS5 (0.78) | ADAMTS5MMP2ADAMTS4ADAM17 | |
| SCHEMBL17871497 | 0.86 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAMTS4ADAM17 | |
| SCHEMBL17871336 | 0.86 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAMTS4ADAM17 | |
| SCHEMBL17871395 | 0.86 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAMTS4ADAM17 | |
| SCHEMBL17884860 | 0.86 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL19759026 | 0.85 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAMTS4ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108579-B | Imidazolidine-2, 4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | 加拉帕戈斯股份有限公司 | 2019-12-17 | — | — | CN | disclosed |