Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 5/20 | 0.53 |
| ▸ | CA1 | P00915 | 5/20 | 0.53 |
| ▸ | CA2 | P00918 | 5/20 | 0.53 |
| ▸ | CA9 | Q16790 | 5/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21601198 | 0.85 | CA12 (0.60) | PDK2CA12CA1CA2CA9 | |
| SCHEMBL1683350 | 0.84 | CA12 (0.64) | PDK2CA12CA1CA2CA9 | |
| SCHEMBL28350739 | 0.83 | PDK2 (0.56) | PDK2CA12CA1CA2CA9 | |
| SCHEMBL29509110 | 0.82 | CA12 (0.56) | PDK2CA12CA1CA2CA9 | |
| SCHEMBL18290008 | 0.82 | CA12 (0.56) | PDK2CA12CA1CA2CA9 | |
| SCHEMBL21601185 | 0.81 | CA12 (0.57) | PDK2CA12CA1CA2CA9 | |
| SCHEMBL28351078 | 0.81 | PPARA (0.53) | PDK2CA12CA1CA2CA9 | |
| SCHEMBL7428314 | 0.79 | SCN9A (0.53) | PDK2CA12CA1CA2CA9 | |
| SCHEMBL22809649 | 0.79 | PDK2 (0.45) | PDK2SCN9AEPHX2 | |
| SCHEMBL3585001 | 0.79 | CA12 (0.67) | PDK2CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110612285-B | Amide derivatives as Nav1.7 and Nav1.8 blockers | 拉夸里亚创药株式会社 | 2023-04-04 | — | — | CN | disclosed |
| CN-110612285-A | Amide derivatives as Nav1.7 and Nav1.8 blockers | 拉夸里亚创药株式会社 | 2019-12-24 | — | — | CN | disclosed |