Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.78 |
| ▸ | CNR2 | P34972 | 5/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1421026 | 0.88 | FAAH (1.00) | FAAHCNR2POLBEPHX2EPHX1 | |
| SCHEMBL2917775 | 0.86 | CNR2 (1.00) | FAAHCNR2POLBEPHX2EPHX1 | |
| SCHEMBL22308141 | 0.85 | FAAH (0.82) | FAAHCNR2POLBEPHX2EPHX1 | |
| SCHEMBL7122051 | 0.85 | POLB (1.00) | FAAHCNR2POLBEPHX1PKM | |
| SCHEMBL11450782 | 0.85 | CNR2 (0.73) | FAAHCNR2POLBPKMTSHR | |
| SCHEMBL19736415 | 0.82 | CNR2 (0.76) | FAAHCNR2POLBEPHX2EPHX1 | |
| SCHEMBL21292793 | 0.82 | CNR2 (0.69) | FAAHCNR2POLBEPHX1PKM | |
| SCHEMBL21309851 | 0.82 | CNR2 (0.69) | FAAHCNR2POLBEPHX1PKM | |
| SCHEMBL2913054 | 0.82 | FAAH (0.71) | FAAHCNR2POLBEPHX2EPHX1 | |
| SCHEMBL16872821 | 0.81 | FAAH (0.71) | FAAHCNR2POLBEPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110759889-B | 2-aryl amido substituted thiophene imide ester compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2022-05-20 | — | — | CN | disclosed |
| CN-110759889-A | 2-aryl amido substituted thiophene imide ester compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2020-02-07 | — | — | CN | disclosed |