Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.64 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28883848 | 0.87 | NOTUM (0.64) | NOTUMHSD17B3CREBBPKMT2AHTT | |
| SCHEMBL26817417 | 0.83 | NOTUM (0.62) | NOTUMHSD17B3HTTBRD4NPC1 | |
| SCHEMBL28360648 | 0.83 | NOTUM (0.62) | NOTUMSRD5A1HSD17B3BRD4MAPT | |
| SCHEMBL28360666 | 0.79 | NOTUM (0.57) | NOTUMHSD17B3BRD4 | |
| SCHEMBL14294095 | 0.78 | NOTUM (1.00) | NOTUMHSD17B3KMT2AHTTSMN1; SMN2 | |
| SCHEMBL28360647 | 0.78 | NOTUM (0.56) | NOTUMHTTSMN1; SMN2KDM4EMAPT | |
| SCHEMBL31129829 | 0.78 | NOTUM (0.56) | NOTUMKMT2ASMN1; SMN2BRD4LMNA | |
| SCHEMBL7220138 | 0.77 | NOTUM (0.43) | NOTUMHSD17B3CREBBPKMT2ASMN1; SMN2 | |
| SCHEMBL31130045 | 0.76 | NOTUM (0.54) | NOTUMKMT2ASMN1; SMN2TSHRBRD4 | |
| SCHEMBL5540524 | 0.74 | SRD5A1 (0.43) | SRD5A1KMT2ASMN1; SMN2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110804008-A | 1, 3-disubstituted indoline derivative and preparation method thereof | 陕西科技大学 | 2020-02-18 | — | — | CN | disclosed |