Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.57 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7860753 | 0.84 | CXCR1 (0.54) | EPHX1RAB9ANPC1CXCR1CXCR2 | |
| SCHEMBL7860746 | 0.84 | CXCR1 (0.54) | EPHX1RAB9ANPC1CXCR1CXCR2 | |
| SCHEMBL7860750 | 0.84 | CXCR1 (0.54) | EPHX1RAB9ANPC1CXCR1CXCR2 | |
| SCHEMBL30878771 | 0.82 | L3MBTL1 (0.63) | EPHX1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL5595104 | 0.82 | CXCR1 (0.80) | RAB9ANPC1CXCR1CXCR2KMT2A | |
| SCHEMBL29113582 | 0.81 | KMT2A (0.59) | RAB9ACXCR1CXCR2KMT2AMEN1 | |
| Urea SCHEMBL7864346 | 0.81 | CXCR1 (0.51) | EPHX1RAB9ANPC1CXCR1CXCR2 | |
| SCHEMBL21862006 | 0.81 | KMT2A (0.62) | EPHX1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL4346187 | 0.81 | EPHX1 (0.63) | EPHX1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL7860578 | 0.80 | CXCR2 (0.51) | EPHX1RAB9ANPC1CXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185562-B1 | PYRROLOPYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-02 | — | — | EP | disclosed |
| EP-2170827-B1 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | JANSSEN PHARMACEUTICA NV (BE) | 2013-08-14 | — | — | EP | disclosed |
| US-8338422-B2 | Indolin-2-ones and aza-indolin-2-ones | JANSSEN PHARMACEUTICA NV (BE) | 2012-12-25 | — | — | US | disclosed |
| US-20100190786-A1 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-29 | — | — | US | disclosed |
| EP-2170827-A2 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | Janssen Pharmaceutica, N.V. (BE) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008155421-A2 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-24 | — | — | WO | disclosed |
| EP-0912505-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6133319-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-17 | — | — | US | disclosed |
| EP-0912505-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997049680-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190786-A1 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | IDO2, IDO1, MKI67 | EPHX1 3609/4885RAB9A 2637/4885NPC1 3076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.