Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 | P28472 | 20/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 13/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 13/20 | 0.47 |
| ▸ | GABRP | O00591 | 10/20 | 0.47 |
| ▸ | GABRD | O14764 | 10/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 10/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 10/20 | 0.47 |
| ▸ | GABRE | P78334 | 10/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 10/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 10/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 10/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 10/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2837035 | 0.94 | GABRB3 (0.42) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2842449 | 0.90 | GABRB3 (0.48) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL13134022 | 0.89 | GABRB3 (0.52) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2839227 | 0.89 | GABRB3 (0.49) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2839909 | 0.89 | GABRB3 (0.47) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL6055918 | 0.88 | GABRB3 (0.53) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2835891 | 0.87 | GABRB3 (0.42) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL15887488 | 0.87 | GABRB3 (0.48) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2833440 | 0.86 | GABRB3 (0.41) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2839903 | 0.86 | GABRB3 (0.34) | GABRB3GABRA2GABRB2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780378-B1 | New 1-aryl pyrazole derivatives and their use as pesticides | BAYER CROPSCIENCE SA (FR) | 2003-04-09 | — | — | EP | claimed |
| EP-0780378-A1 | New 1-aryl pyrazole derivatives and their use as pesticides | RHONE-POULENC AGROCHIMIE (FR) | 1997-06-25 | — | — | EP | claimed |
| US-9339033-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9339033-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9339033-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| EP-2035390-B1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL INC (US) | 2015-12-09 | — | — | EP | disclosed |
| US-20150133506-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | AVENTIS AGRICULTURE (FR) | 2015-05-14 | — | — | US | disclosed |
| US-20150133506-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | AVENTIS AGRICULTURE (FR) | 2015-05-14 | — | — | US | disclosed |
| US-20150133506-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | AVENTIS AGRICULTURE (FR) | 2015-05-14 | — | — | US | disclosed |
| US-8785372-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | AVENTIS AGRICULTURE | 2014-07-22 | — | — | US | disclosed |
| US-8785372-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | AVENTIS AGRICULTURE | 2014-07-22 | — | — | US | disclosed |
| WO-2008005489-A2 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | AVENTIS AGRICULTURE (FR) | 2008-01-10 | — | — | WO | disclosed |
| EP-0780378-B1 | New 1-aryl pyrazole derivatives and their use as pesticides | BAYER CROPSCIENCE SA (FR) | 2003-04-09 | — | — | EP | disclosed |
| US-6395906-B1 | PESTICIDES | RHONE-POULENC INC. | 2002-05-28 | — | — | US | disclosed |
| US-6180798-B1 | CHEMICAL INTERMEDIATES FOR INSECTICIDES AND PESTICIDES | RHONE-POULENC INC. | 2001-01-30 | — | — | US | disclosed |
| US-6124339-A | INSECTICIDES AND NEMATICIDES | RHONE-POULENC INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-5994386-A | INSECTICIDES, NEMATOCIDES | RHONE-POULENC INC. (US) | 1999-11-30 | — | — | US | disclosed |
| US-5922885-A | FOR AGRICULTURAL CROPS | RHONE-POULENC INC. (US) | 1999-07-13 | — | — | US | disclosed |
| US-5817688-A | FOR AGRICULTURAL CROPS; INSECTICIDES, NEMATOCIDES | RHONE-POULENC INC. (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0780378-A1 | New 1-aryl pyrazole derivatives and their use as pesticides | RHONE-POULENC AGROCHIMIE (FR) | 1997-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133506-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | CBR3, CBR1, NR5A2 | GABRB3 1201/4885GABRA2 1488/4885GABRB2 1394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.