GABRB3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL104133	0.66	20/20
SCHEMBL15406	0.61	20/20
Fipronil (SCHEMBL15088)	0.59	20/20
SCHEMBL41972	0.59	20/20
Fipronil (SCHEMBL44222)	0.59	20/20
Ethiprole (SCHEMBL27048)	0.56	20/20
SCHEMBL25897	0.51	20/20
SCHEMBL104346	0.68	19/20
SCHEMBL103712	0.67	19/20
SCHEMBL33214	0.52	19/20
SCHEMBL26584	0.51	19/20
Flumazenil (SCHEMBL79030)	1.00	16/20
Iomazenil (SCHEMBL41658)	0.71	12/20
SCHEMBL9107	0.56	12/20
SCHEMBL8532	1.00	11/20
SCHEMBL9035	0.56	10/20
SCHEMBL8632	0.54	10/20
SCHEMBL8670	0.57	9/20
SCHEMBL8856	0.53	9/20
SCHEMBL9273	0.53	9/20

Clinical trials — most relevant to GABRB3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Computational Assessment of GABA Receptor Modulation in PTSD	PHASE4	RECRUITING
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence.	PHASE4	COMPLETED
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
Clonazepam Effects on Brain Oscillations and Cognition in Schizophrenia	PHASE4	WITHDRAWN
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex	PHASE4	COMPLETED
Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery	PHASE4	RECRUITING
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia	PHASE2	COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy	PHASE1/PHASE2	WITHDRAWN
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome	PHASE2	RECRUITING
Effects of Baclofen on Presynaptic Inhibition in Humans	PHASE2	WITHDRAWN
PET Imaging of Brain Peripheral Benzodiazepine Receptors	PHASE1	COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28	PHASE1	COMPLETED
MEG Study of Acute STX209 Effects in ASD	EARLY_PHASE1	COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T	EARLY_PHASE1	UNKNOWN
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
GABA Biomarkers in Dravet Syndrome	nan	RECRUITING
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy	nan	ENROLLING_BY_INVITATION
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain	nan	UNKNOWN
Brain Changes in Patients With Focal Hand Dystonia	nan	COMPLETED
Butyrate Supplementation in Children With Autism Spectrum Disorder (ASD) and Functional Gastrointestinal Disorders	nan	RECRUITING
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory	nan	COMPLETED
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain.	nan	RECRUITING
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain	nan	RECRUITING
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk	nan	COMPLETED
L-arginine add-on Therapy in Patients With Schizophrenia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GABRB3 binder may also engage these)

Protein	Name	Similarity
P63079	—	1.000	P63079 →
P19019	—	1.000	P19019 →
P63080	—	1.000	P63080 →
P0C2W5	—	0.998	P0C2W5 →
P63138	—	0.997	P63138 →
GABRB1	Gamma-aminobutyric acid receptor subunit beta-1	0.997	landscape →
P50571	—	0.997	P50571 →
P15431	—	0.996	P15431 →
GABRB2	Gamma-aminobutyric acid receptor subunit beta-2	0.995	landscape →
P08220	—	0.995	P08220 →
P63137	—	0.994	P63137 →
D1LYT2	—	0.987	D1LYT2 →
P23576	—	0.970	P23576 →
Q5RCC5	—	0.968	Q5RCC5 →
P27681	—	0.967	P27681 →
P28473	—	0.965	P28473 →
GABRA5	Gamma-aminobutyric acid receptor subunit alpha-5	0.965	landscape →
P10063	—	0.965	P10063 →
P19969	—	0.965	P19969 →
P26048	—	0.965	P26048 →
GABRG3	Gamma-aminobutyric acid receptor subunit gamm	0.965	landscape →
P62812	—	0.964	P62812 →
P62813	—	0.963	P62813 →
Q4R534	—	0.963	Q4R534 →
Q8BHJ7	—	0.962	Q8BHJ7 →
GABRA2	Gamma-aminobutyric acid receptor subunit alpha-2	0.962	landscape →
P18508	—	0.962	P18508 →
P08219	—	0.961	P08219 →
Q5R6B2	—	0.960	Q5R6B2 →
P21548	—	0.959	P21548 →