Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 9/20 | 0.67 |
| ▸ | JAK2 | O60674 | 6/20 | 0.67 |
| ▸ | JAK1 | P23458 | 4/20 | 0.67 |
| ▸ | JAK3 | P52333 | 4/20 | 0.67 |
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552906 | 1.00 | TYK2 (0.67) | TYK2JAK2JAK1JAK3NNMT | |
| SCHEMBL29552360 | 0.94 | TYK2 (0.65) | TYK2JAK2JAK1JAK3MEN1 | |
| SCHEMBL29552312 | 0.87 | TYK2 (0.58) | TYK2JAK2JAK1JAK3MEN1 | |
| SCHEMBL28362682 | 0.87 | TYK2 (0.58) | TYK2JAK2JAK1JAK3MEN1 | |
| SCHEMBL29552169 | 0.87 | TYK2 (0.58) | TYK2JAK2JAK1JAK3MEN1 | |
| SCHEMBL28359242 | 0.85 | TYK2 (0.75) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28358935 | 0.84 | TYK2 (0.61) | TYK2JAK2JAK1JAK3SYK | |
| SCHEMBL29552180 | 0.83 | TYK2 (0.60) | TYK2JAK2JAK1JAK3SYK | |
| SCHEMBL28359026 | 0.83 | TYK2 (0.60) | TYK2JAK2JAK1JAK3SYK | |
| SCHEMBL29551888 | 0.79 | JAK2 (0.59) | TYK2JAK2JAK1JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |