Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.59 |
| ▸ | JAK1 | P23458 | 7/20 | 0.59 |
| ▸ | TYK2 | P29597 | 7/20 | 0.59 |
| ▸ | JAK3 | P52333 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ILK | Q13418 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552249 | 0.90 | TYK2 (0.58) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL28359236 | 0.90 | TYK2 (0.58) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL28362555 | 0.89 | JAK1 (0.52) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29551925 | 0.89 | JAK1 (0.52) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29551923 | 0.87 | TYK2 (0.55) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL28884120 | 0.87 | TYK2 (0.55) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL28363100 | 0.87 | JAK2 (0.57) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL28359205 | 0.86 | JAK2 (0.56) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL29922823 | 0.85 | JAK2 (0.51) | JAK2JAK1TYK2JAK3SIRT2 | |
| SCHEMBL28362706 | 0.85 | JAK2 (0.55) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |