Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.64 |
| ▸ | TYK2 | P29597 | 8/20 | 0.64 |
| ▸ | JAK1 | P23458 | 7/20 | 0.64 |
| ▸ | JAK3 | P52333 | 7/20 | 0.64 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552138 | 1.00 | JAK2 (0.64) | JAK2TYK2JAK1JAK3TRPV1 | |
| SCHEMBL29552215 | 0.93 | JAK2 (0.54) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL28359103 | 0.93 | JAK2 (0.54) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL28359046 | 0.91 | JAK2 (0.60) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL29552451 | 0.91 | JAK2 (0.60) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL28359167 | 0.85 | JAK2 (0.69) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL29551995 | 0.85 | JAK2 (0.69) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL28359255 | 0.85 | JAK2 (0.62) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL29552028 | 0.85 | JAK2 (0.62) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL29552328 | 0.84 | JAK2 (0.51) | JAK2TYK2JAK1JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |