Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.69 |
| ▸ | TYK2 | P29597 | 10/20 | 0.69 |
| ▸ | JAK1 | P23458 | 9/20 | 0.69 |
| ▸ | JAK3 | P52333 | 9/20 | 0.69 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | YES1 | P07947 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359167 | 1.00 | JAK2 (0.69) | JAK2TYK2JAK1JAK3AURKA | |
| SCHEMBL29552249 | 0.92 | TYK2 (0.58) | JAK2TYK2JAK1JAK3AURKA | |
| SCHEMBL28359236 | 0.92 | TYK2 (0.58) | JAK2TYK2JAK1JAK3AURKA | |
| SCHEMBL29551876 | 0.87 | TYK2 (0.66) | JAK2TYK2JAK1JAK3AURKA | |
| SCHEMBL28359071 | 0.87 | TYK2 (0.66) | JAK2TYK2JAK1JAK3AURKA | |
| SCHEMBL29552028 | 0.86 | JAK2 (0.62) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL29552138 | 0.85 | JAK2 (0.64) | JAK2TYK2JAK1JAK3RAB9A | |
| SCHEMBL28359283 | 0.85 | JAK2 (0.64) | JAK2TYK2JAK1JAK3RAB9A | |
| SCHEMBL28359124 | 0.85 | JAK2 (0.66) | JAK2TYK2JAK1JAK3SYK | |
| SCHEMBL29551888 | 0.83 | JAK2 (0.59) | JAK2TYK2JAK1JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |