Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | S100A4 | P26447 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16880599 | 1.00 | MAPT (0.58) | MAPTALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL16398981 | 0.88 | MAPT (0.69) | MAPTALDH1A1POLBKMT2AHTT | |
| SCHEMBL21848210 | 0.84 | MAPT (0.74) | MAPTALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL21848251 | 0.83 | MAPT (0.63) | MAPTALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL22149667 | 0.82 | ALDH1A1 (0.54) | MAPTALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL16880167 | 0.82 | ALDH1A1 (0.54) | MAPTALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL29891157 | 0.82 | ALDH1A1 (0.54) | MAPTALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL16880245 | 0.82 | MAPT (0.61) | MAPTALDH1A1POLBSMN1; SMN2RAB9A | |
| SCHEMBL30608491 | 0.80 | ALDH1A1 (0.55) | MAPTALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL14511129 | 0.78 | MAPT (0.53) | MAPTALDH1A1POLBSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678461-B | Syk inhibitors and methods of use thereof | 正大天晴药业集团股份有限公司 | 2021-08-10 | — | — | CN | disclosed |
| CN-110678461-A | Syk inhibitors and methods of use thereof | 正大天晴药业集团股份有限公司 | 2020-01-10 | — | — | CN | disclosed |